Abstract
New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.
MeSH terms
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Alkylation
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Chemical Phenomena
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Chemistry, Physical
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Indicators and Reagents
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Peptide Library
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Pyridones / chemical synthesis*
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Pyridones / pharmacology*
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Receptors, Opioid, delta / chemistry
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Receptors, Opioid, delta / metabolism
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Receptors, Opioid, kappa / agonists*
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Receptors, Opioid, kappa / chemistry
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Receptors, Opioid, mu / chemistry
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Receptors, Opioid, mu / metabolism
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Solutions
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Structure-Activity Relationship
Substances
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Indicators and Reagents
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Peptide Library
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Pyridones
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Receptors, Opioid, delta
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
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Solutions